On Matchday 16, Eintracht Frankfurt defeated St. Pauli by a slim margin of 1-0 at the Millerntor Stadion, thanks to a goal by Omar Marmoush in the first half. Eintracht Frankfurt dominated the first half, controlling possession and generating many opportunities. Marmoush was very aggressive and put Nikola Vasilj to the test right away. In the 32nd minute, Marmoush scored from close range after taking advantage of a defensive blunder. Marmoush's 14th goal of the season tied him with Harry Kane at the top of the goalscoring lists, underscoring his significance to Frankfurt's campaign. St. Pauli had their chances, but Carlo Boukhalfa hit the post in stoppage time in the first half.

A revitalized St. Pauli team made a valiant effort to equalize in the second half. Frankfurt's defenders held tight to win the match despite pressure from St. Pauli, including a late shot by Scott Banks that hit the crossbar.